Risky sexual behaviour among adolescents with visual impairment has continued to be a source of concern to different tiers of government, parents, teachers and members of society at large. Several studies on adolescents with visual impairment have been on their academic achievement and the development of daily living skills, with little or no studies devoted to their participation in risky sexual activities. This study, therefore, focused on school climate and gender as factors in risky sexual behaviour among adolescents with visual impairment in Southwestern, Nigeria. Health Belief Model and Social Learning Theory provided the framework for the study. Descriptive research design of correlational type was adopted using purposive sampling technique to select twelve integrated schools in six Southwestern States (Ekiti-1, Lagos -4, Ogun – 4, Ondo – 1, Osun-1 and Oyo-1). Snellen’s chart was used to screen adolescents with visual impairment to ascertain their visual acuity.  Afterwards, a total enumeration of three hundred and eleven (311) adolescents with visual impairment was adopted. Average age of the respondents was + 17 years old. Data was collected through the school Climate Student Scale (a =.92) and Adolescents Risky Behaviour Questionnaire (a =.73). Data collected were analysed using  descriptive statistics, Pearson Product Moment Correlation and t-test. Findings showed that there was a significant relationship between school climate and risky sexual behaviour among adolescents with visual impairment. The study also revealed a significant gender difference in risky sexual behaviour among adolescents with visual impairment in Oyo State. Based on the findings, it was recommended that school administrators, special educators, and counsellors should help the adolescents with visual impairment to recognise and appreciate the roles and impact of the school environment in shaping their lifestyles and dispositions towards reducing risky sexual behaviour among them.