The study investigated some determinants of academic resilience among post-secondary school students with hearing impairment in Oyo State,
Nigeria. It examined learning self-efficacy, perceived social support, locus of control and study habit as determinants of academic resilience. The data collected were analysed using Pearson product moment correlation and multiple regression R = 0.641, p <.05. The results further revealed 38% (Adj. R2 = 0.380) of the variance in the students’ academic resilience among post-secondary school students with hearing impairment in Oyo state of Nigeria were accountable for by the linear combination of the independent variables. Social support was the most significant contributor of academic resilience (β = 0.379, t = 3.857, p < 0.05) (β = -0.512 , followed by study habit , t = 5.304, p < 0.05), locus of control , and learning self-efficacy < 0.05). The study recommends that parents and other education stakeholders should provide essential support to students with hearing impairment to enhance their academic resilience. Also, the general public should be enlightened about the determinants investigated in the study. Implications of the results and directions for future research are provided.